Kings fly-half Lionel Cronje will captain the side in the absence of Schalk Ferreira for their match against the Lions in Port Elizabeth.
Warren Whiteley will captain the Lions for the 50th time in Super Rugby when his side face off with the Kings in Port Elizabeth on Saturday.
Reds head coach Nick Stiles has chosen to rest George Smith and Rob Simmons for Saturday’s game against the Jaguares at Vélez Sarsfield.
The Sharks have made six changes to their starting line-up that scraped past the Kings last weekend to play the Cheetahs in Bloemfontein.
Cheetahs centre Francois Venter will be making his return from an ankle injury that kept him sidelined for the first four games of Super Rugby.
Ulster back-row Marcell Coetzee will be out for the rest of the season after he had surgery on the knee injury he sustained recently.
New Zealand Rugby boss Steve Tew admitted that the silence on Super Rugby’s proposed changes is frustrating but said it took time.
Bulls midfielder Jan Serfontein will make a 50th appearance for his team on Saturday when they face the Blues in Albany.
Stormers head coach Robbie Fleck has made several changes to his starting XV for Saturday’s clash with the Sunwolves in Singapore.
Six Grenoble players have been detained following an alleged rape of a woman on Saturday.